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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPF All Species: 9.7
Human Site: S1123 Identified Species: 17.78
UniProt: P49454 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49454 NP_057427.3 3210 367764 S1123 D N Q N N S K S E A G G L K Q
Chimpanzee Pan troglodytes XP_001171549 3114 357698 S1123 D N Q N N S K S E P G G L K Q
Rhesus Macaque Macaca mulatta XP_001105956 3113 357422 S1123 D T R N N S K S E T D G L K Q
Dog Lupus familis XP_852813 1449 166096
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510329 2965 340022 A1113 R V Q G A F K A E I E E I Q N
Chicken Gallus gallus O42184 1433 161009
Frog Xenopus laevis P85120 2058 236320 S259 L A V E L A E S K A K L R R I
Zebra Danio Brachydanio rerio XP_002665261 2708 311087 K909 E T R S S L E K V K E L Q V Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJE5 1690 189046
Honey Bee Apis mellifera XP_001120388 2064 240016 L265 C E Q T V A N L T K E L E E K
Nematode Worm Caenorhab. elegans P02566 1966 225108 D167 A Y R N M L Q D H E N Q S M L
Sea Urchin Strong. purpuratus XP_796801 3636 416057 E1331 E S T R C N E E F T L K F E Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P25386 1790 206434
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.8 91.4 32.8 N.A. N.A. N.A. N.A. 50.5 20.4 21.5 31.3 N.A. 21.3 22.9 20.1 22
Protein Similarity: 100 96.4 93.8 39.1 N.A. N.A. N.A. N.A. 67.5 32.4 38.6 51.2 N.A. 35.2 41.3 36.4 43.7
P-Site Identity: 100 93.3 73.3 0 N.A. N.A. N.A. N.A. 20 0 13.3 6.6 N.A. 0 6.6 6.6 6.6
P-Site Similarity: 100 93.3 80 0 N.A. N.A. N.A. N.A. 40 0 40 40 N.A. 0 26.6 20 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 36.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 0 8 16 0 8 0 16 0 0 0 0 0 % A
% Cys: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 24 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % D
% Glu: 16 8 0 8 0 0 24 8 31 8 24 8 8 16 0 % E
% Phe: 0 0 0 0 0 8 0 0 8 0 0 0 8 0 0 % F
% Gly: 0 0 0 8 0 0 0 0 0 0 16 24 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 8 % I
% Lys: 0 0 0 0 0 0 31 8 8 16 8 8 0 24 8 % K
% Leu: 8 0 0 0 8 16 0 8 0 0 8 24 24 0 8 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 16 0 31 24 8 8 0 0 0 8 0 0 0 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % P
% Gln: 0 0 31 0 0 0 8 0 0 0 0 8 8 8 39 % Q
% Arg: 8 0 24 8 0 0 0 0 0 0 0 0 8 8 0 % R
% Ser: 0 8 0 8 8 24 0 31 0 0 0 0 8 0 0 % S
% Thr: 0 16 8 8 0 0 0 0 8 16 0 0 0 0 0 % T
% Val: 0 8 8 0 8 0 0 0 8 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _